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Welcome to our research page featuring recent publications in the field of biostatistics and epidemiology! These fields play a crucial role in advancing our understanding of the causes, prevention, and treatment of various health conditions. Our team is dedicated to advancing the field through innovative studies and cutting-edge statistical analyses. On this page, you will find our collection of research publications describing the development of new statistical methods and their application to real-world data. Please feel free to contact us with any questions or comments.

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Predicting disability progression in multiple sclerosis: Insights from advanced statistical modeling

Background: There is an unmet need for precise methods estimating disease prognosis in multiple sclerosis (MS).

Objective: Using advanced statistical modeling, we assessed the prognostic value of various clinical measures for disability progression.

Methods: Advanced models to assess baseline prognostic factors for disability progression over 2 years were applied to a pooled sample of patients from placebo arms in four different phase III clinical trials. Least absolute shrinkage and selection operator (LASSO) and ridge regression, elastic nets, support vector machines, and unconditional and conditional random forests were applied to model time to clinical disability progression confirmed at 24 weeks. Sensitivity analyses for different definitions of a combined endpoint were carried out, and bootstrap was used to assess prediction model performance.

Results: A total of 1582 patients were included, of which 434 (27.4%) had disability progression in a combined endpoint over 2 years. Overall model discrimination performance was relatively poor (all C-indices ≤ 0.65) across all models and across different definitions of progression.

Conclusion: Inconsistency of prognostic factor importance ranking confirmed the relatively poor prediction ability of baseline factors in modeling disease progression in MS. Our findings underline the importance to explore alternative predictors as well as alternative definitions of commonly used endpoints.

Journal: Multiple Sclerosis Journal |
Year: 2020
Citation: 11