Practicalities Of Using Real-World Evidence (RWE) In Comparative Effectiveness Research (CER)

Makady A, Stegenga H, Ciaglia A, Debray T, Lees M, Ryll B, Abrams K, Thwaites R, Garner S, Jonsson P, Goettsch W

The IMI-GetReal project aimed to explore incorporation of robust methods for real-world evidence (RWE) collection and synthesis in the medicines development process, both by pharmaceutical companies and healthcare decision makers. The focus was on the potential use of RWE, alone or in combination with randomized controlled trials (RCTs), to demonstrate effectiveness of new interventions. Seven case studies were conducted in multiple disease areas to examine methods for predicting drug effectiveness and the perspectives of different stakeholders on these methods.