Systematic reviews of prognostic studies IV: meta-analysis of prognostic studies using individual participant data

Systematic reviews of prognostic studies IV: meta-analysis of prognostic studies using individual participant data
Speaker: Thomas Debray
  • 18th Sep 2018
  • 11:00 AM TO 12:30 PM
  • 25th Cochrane Colloquium
  • Edinburgh, The United Kingdom

Background: The development and validation of prediction models is an important area in contemporary medical research. Over the past few years, evidence synthesis and meta-analysis of individual participant data (IPD) has become increasingly popular, not only for intervention research but also for improving the development, validation and generalisability of prediction models. IPD meta-analyses (IPD-MA) provide unique opportunities to better develop and enhance the applicability of prediction models across (sub)populations and settings. There is, however, little guidance on how to conduct an IPD-MA aimed at developing and validating diagnostic and prognostic prediction models, and how to interpret the findings.

Objectives: This workshop introduces IPD meta-analysis in risk prediction research and the required statistical methodology. We will illustrate the implementation of IPD meta-analysis using case studies and example papers.

Description: We will discuss how IPD-MA aimed at developing and validating prediction models differ from IPD-MA for assessing treatment effects. We will identify key advantages and challenges in IPD-MA of prediction models. We will provide recommendations for the design of such IPD-MA including the selection of relevant studies. We will discuss statistical methods for handling between-study heterogeneity and other issues regarding prediction model development and validation. We will illustrate this using various empirical examples across medical disciplines.

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