Systematic reviews of prognostic studies III: meta-analytical approaches in systematic reviews of prognostic studies

Systematic reviews of prognostic studies III: meta-analytical approaches in systematic reviews of prognostic studies
Speaker: Thomas Debray
  • 17th Sep 2018
  • 11:00 AM TO 12:30 PM
  • 25th Cochrane Colloquium
  • Edinburgh, The United Kingdom

Background: Prediction models are commonly developed and validated for predicting the presence (diagnostic) or future occurrence (prognostic) of a particular outcome. Prediction models have become abundant in the literature. Many models have been validated in numerous different studies/publications. In addition, numerous studies have investigated the (added) value of a prognostic factor/predictor/biomarker to existing predictors. In both situations, aggregating such data is important for making inferences on the predictive performance of a specific model or predictor/marker. Meta-analytical approaches for both situations have recently been developed.

Objectives: This workshop introduces participants to statistical methods for meta-analysis in systematic reviews of prognosis studies. We address both meta-analysis of the accuracy of a prognostic model and of the (added) predictive value of a prognostic factor. We discuss the opportunities/challenges of the statistical methods and common software packages.

Description: In this workshop we illustrate these statistical approaches and how to combine - quantitatively - results from published studies on the predictive accuracy of a prognostic model or (added) predictive accuracy of a prognostic factor. We illustrate this with various empirical examples.

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