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External validation of clinical prediction models using big datasets from e-health records or IPD meta-analysis: opportunities and challenges

Riley RD, Ensor J, Snell KI, Debray TP, Altman DG, Moons KG, Collins GS

Access to big datasets from e-health records and individual participant data (IPD) meta-analysis is signalling a new advent of external validation studies for clinical prediction models. In this article, the authors illustrate novel opportunities for external validation in big, combined datasets, while drawing attention to methodological challenges and reporting issues.

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Projects: Clinical prediction rules: towards a framework for meta-analysis, validation, and updating,