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Systematic reviews on the prognostic role of biomarkers in heart failure

Heart failure (HF) is characterised by high morbidity and mortality. The measurement of established biomarkers like the natriuretic peptide family (BNP, NT-proBNP, MR-proANP) and mid-regional proadrenomedullin (MR-proADM) may improve prognostic stratification and timely treatment for HF patients. We propose a series of five systematic reviews to identify and appraise prognostic studies of these biomarkers, and explore their added prognostic value for HF patient-relevant outcomes.

The reviews will be carried out following the conduct and reporting standards of Cochrane exemplar prognostic reviews. We will use novel prognostic model development and evaluation methodology in these reviews. We aim to make recommendations for future design and conduct of HF prognostic studies. These results may increase clinician awareness of prognostic modelling, leading to biomarkers-guided HF therapy. This may improve patient outcomes by ensuring intensive treatment is begun proactively rather than reactively in identified HF patients.

Project Details

FunderBritish Heart Foundation
Project ReferencePG/17/49/33099
Funded PeriodAug 2017 - Jul 2019
Funded ValueGBP 129,967
LeadDr. Marialena Trivella - ORCID iD
Cooperating centers